Synthesis and Antimicrobial activity of Novel Isoxazolines by 1, 3-Dipolar Cycloaddition Reactions
نویسندگان
چکیده
Nitrile oxides were generated by the catalytic dehydrogenation of aromatic aldehyde oximes 2a-g with chloramine-T as oxidizing agent. The 1,3-dipolar cycloaddition of in situ generated nitrile oxides with ethyl oleate 1 produced a series of new ethyl 8-(3-aryl-4-octyl-4,5-dihydroisoxazol-5-yl)octanoate 3a-g in 6584% yield. Some of the synthesized cycloadducts have exhibited moderate to good antifungal and antibacterial activity.
منابع مشابه
Synthesis of some novel class of isoxazoline and isoxazolidine derivatives in ionic liquid via 1,3-dipolar cycloaddition reaction of dihydropyran derived nitrones and their antimicrobial activities
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